Occasionally a situation may be encountered when an alternative to oral administration of contraceptive pills is required. For example, patients receiving chemotherapy can either have significant nausea and vomiting, or mucocitis, both of which would prevent oral drug administration. The little dose oral contraceptives can be administered vaginally. Initially it was claimed that two pills must be placed high in the vagina daily in order to produce contraceptive steroid blood levels comparable to the oral administration of one pill. However, a large clinical trial has demonstrated typical contraceptive efficacy with one pill per day.